Description
p-SCN-Bn-DOTA, CAS NO. 127985-74-4, is a bifunctional chelating agent. p-SCN-Bn-DOTA can simultaneously chelate radionuclides and link monoclonal antibody for radioimmunotherapy of tumor.
Product information
CAS Number: 127985-74-4
Molecular Weight: 551.61
Formula: C24H33N5O8S
Synonym:
2-[4,7,10-tris(carboxymethyl)-5-[(4-isothiocyanatophenyl)methyl]-1,4,7,10-tetraazacyclododecan-1-yl]acetic acid
Chemical Name: 2-[4, 7, 10-tris(carboxymethyl)-6-[(4-isothiocyanatophenyl)methyl]-1, 4, 7, 10-tetrazacyclododec-1-yl]acetic acid
Smiles: OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)C(CC2C=CC(=CC=2)N=C=S)CN(CC(O)=O)CC1
InChiKey: UDOPJKHABYSVIX-UHFFFAOYSA-N
InChi: InChI=1S/C24H33N5O8S/c30-21(31)13-26-5-6-27(14-22(32)33)9-10-29(16-24(36)37)20(12-28(8-7-26)15-23(34)35)11-18-1-3-19(4-2-18)25-17-38/h1-4,20H,5-16H2,(H,30,31)(H,32,33)(H,34,35)(H,36,37)
Technical Data
Appearance: Solid Power
Purity: ≥97% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
p-SCN-Bn-DOTA is complexed with 5 different metal ions: In(III), Y(III), Lu(III), Gd(III) and Cu(II).
References:
- Giannini G, et, al. Synthesis and preliminary in vitro evaluation of DOTA-Tenatumomab conjugates for theranostic applications in tenascin expressing tumors. Bioorg Med Chem. 2019 Aug 1;27(15):3248-3253.
- Vera DRB, et, al. Preclinical evaluation of (177)lu-nimotuzumab: a potential tool for radioimmunotherapy of epidermal growth factor receptor-overexpressing tumors. Cancer Biother Radiopharm. 2011 Jun;26(3):287-97.
Products are for research use only. Not for human use.
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