Description
Antiproliferative agent-60 (8c) is a 11-Azaartemisinin derivative with superior anticancer activities. Antiproliferative agent-60 shows IC50 values of 7.7 μM, 42.5 μM, and 15.5 μM for epidermoid carcinoma (KB), HepG2, and A549 cells, respectively. Antiproliferative agent-60 exhibits significant tumor selectivity, up to 32-fold higher compared to Hek293 normal cells.
Product information
Molecular Weight: 517.42
Formula: C24H29BrN4O4
Smiles: C[C@@]12CCC3[C@H](C)CCC4[C@@H](C)C(=O)N(CC5=CN(N=N5)C5=CC(Br)=CC=C5)[C@H](O1)[C@]43OO2
InChiKey: OVDLATYBNREJGN-YGXNPTFSSA-N
InChi: InChI=1S/C24H29BrN4O4/c1-14-7-8-20-15(2)21(30)28(22-24(20)19(14)9-10-23(3,31-22)32-33-24)12-17-13-29(27-26-17)18-6-4-5-16(25)11-18/h4-6,11,13-15,19-20,22H,7-10,12H2,1-3H3/t14-,15-,19?,20?,22-,23-,24-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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