Description
L-659837 is a NK2 receptor antagonist, and can antagonize GR 64349 (HY-P1278)-induced contraction. L-659837 can be used for study of urinary bladder disorders.
Product information
CAS Number: 719277-30-2
Molecular Weight: 277.34
Formula: C14H15NO3S
Smiles: CCN1C2=CC(=CC=C2S/C/1=C\C(C)=O)OC(C)=O
InChiKey: RLEOCVDWLAYGRX-AUWJEWJLSA-N
InChi: InChI=1S/C14H15NO3S/c1-4-15-12-8-11(18-10(3)17)5-6-13(12)19-14(15)7-9(2)16/h5-8H,4H2,1-3H3/b14-7-
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
In the cultured cells overexpressing Dyrk1A or xDyrk1A, ProINDY inhibits the phosphorylation of Thr212 of the tau-protein. ProINDY also rescues the NFAT pathway in Dyrk1A-overexpressing cells, confirming the identical Dyrk1A-inhibitory effect.
Products are for research use only. Not for human use.
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