Description
NOX2-IN-2 diTFA (compound 33) is a potent NOX2 inhibitor targeting the p47phox-p22phox protein-protein interaction with a Ki of 0.24 μM. NOX2-IN-2 diTFA inhibits ROS production derived from NOX2 in cells.
Product information
CAS Number: 2648709-80-0
Molecular Weight: 699.56
Formula: C29H27F6N7O7
Chemical Name: 6-{[1-(2-{2-[(2-aminoquinolin-6-yl)oxy]ethoxy}ethyl)-1H-1, 2, 3-triazol-4-yl]methoxy}quinolin-2-amine; bis(trifluoroacetic acid)
Smiles: NC1=CC=C2C=C(C=CC2=N1)OCC1=CN(CCOCCOC2=CC3=CC=C(N)N=C3C=C2)N=N1.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F
InChiKey: JGVQFWXGKWGPBE-UHFFFAOYSA-N
InChi: InChI=1S/C25H25N7O3.2C2HF3O2/c26-24-7-1-17-13-20(3-5-22(17)28-24)34-12-11-33-10-9-32-15-19(30-31-32)16-35-21-4-6-23-18(14-21)2-8-25(27)29-23;2*3-2(4,5)1(6)7/h1-8,13-15H,9-12,16H2,(H2,26,28)(H2,27,29);2*(H,6,7)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
DMSO : 125 mg/mL (178.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Products are for research use only. Not for human use.
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