Denopterin


Catalog No. Size PriceQuantity
M34456-C Contact sales@xcessbio.com for quotation $100

Description

Denopterin is a dihydrofolate reductase (DHFR) inhibitor and an antifolate agent. Denopterin is an antimetabolite that has toxic effects on cells and can be used for cancer.

Product information

CAS Number: 22006-84-4

Molecular Weight: 469.45

Formula: C21H23N7O6

Smiles: CC(C1=CNC2=NC(N)=NC(=O)C2=N1)N(C)C1C=CC(=CC=1)C(=O)N[C@@H](CCC(O)=O)C(O)=O

InChiKey: FLWWDYNPWOSLEO-HQVZTVAUSA-N

InChi: InChI=1S/C21H23N7O6/c1-10(14-9-23-17-16(24-14)19(32)27-21(22)26-17)28(2)12-5-3-11(4-6-12)18(31)25-13(20(33)34)7-8-15(29)30/h3-6,9-10,13H,7-8H2,1-2H3,(H,25,31)(H,29,30)(H,33,34)(H3,22,23,26,27,32)/t10?,13-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Antibody-drug conjugates (ADCs) have great promise as anti-cancer drugs. In recent years, there has been increasing applications of the pyrrolobenzo-diazepine dimer (PBD) class of cytotoxic payloads as ADC therapeutics due to PBDs’extream potency against most of the US National Cancer Institute’s (NCI’s) NCI 60-tumor-cell line panels along with unique mechanism of antitumor antibiotics activity. All PBDs are usually conjugated to an antibody with one conditionally stable linker, because it is normally believed that linkers of ADCs must be stable while the ADC is circulating in the blood to limit off-target toxicity, but allow for release of the drug once it is inside the target cancer cells.

Products are for research use only. Not for human use.

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