Description
FIN56 is a specific inducer of ferroptosis.
Product information
CAS Number: 1083162-61-1
Molecular Weight: 517.66
Formula: C25H31N3O5S2
Synonym:
FIN-56
FIN56
FIN 56
Chemical Name: N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide
Smiles: ON=C1C2=CC(=CC=C2C2=CC=C(C=C21)S(=O)(=O)NC1CCCCC1)S(=O)(=O)NC1CCCCC1
InChiKey: JLCFMMIWBSZOIS-UHFFFAOYSA-N
InChi: InChI=1S/C25H31N3O5S2/c29-26-25-23-15-19(34(30,31)27-17-7-3-1-4-8-17)11-13-21(23)22-14-12-20(16-24(22)25)35(32,33)28-18-9-5-2-6-10-18/h11-18,27-29H,1-10H2
Technical Data
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
In Vitro:
FIN56 (5 μM) can trigger ferroptosis by inhibition of glutathione peroxidase 4 (GPX4). FIN56 (5 μM, 10 hours) depletes GPX4 protein in HT-1080 cells.
References:
- Shimada K, Skouta R, Kaplan A, Yang WS, Hayano M, Dixon SJ, Brown LM, Valenzuela CA, Wolpaw AJ, Stockwell BR. Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat Chem Biol. 2016 Jul;12(7):497-503. doi: 10.1038/nchembio.2079. Epub 2016 May 9. PubMed PMID: 27159577; PubMed Central PMCID: PMC4920070.
- Kolasa A. [Epididymis in an experimental model of DHT deficiency: immunolocalization of ERalpha and ERbeta in rat epididymal epithelial cells. In vivo and in vitro studies]. Ann Acad Med Stetin. 2006;52(2):13-21; discussion 21. Polish. PubMed PMID: 17633123.
Products are for research use only. Not for human use.
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