Description
Flutamide, also known as SCH13521, is a toluidine derivative and nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
Product information
CAS Number: 13311-84-7
Molecular Weight: 276.21
Formula: C11H11F3N2O3
Synonym:
SCH-13521
SCH13521
SCH-13521
SCH 13521
Flucinom
Flugerel
Niftolid
Eulexin
Apimid
Chimax
Drogenil
Euflex
Eulexine
Flucinome
Fluken
Flulem
Flutabene
Flutacan
FlutaGry
Flutamex
Flutamin
Flutan
Flutaplex
Fugerel
Grisetin
Oncosal
Profamid
Prostacur
Prostadirex
Prostica
Prostogenat
Tafenil
Tecnoflut
Testotard
FLUT
Chemical Name: N-(4-nitro-3-(trifluoromethyl)phenyl)isobutyramide
Smiles: CC(C)C(=O)NC1=CC(=C(C=C1)[N+]([O-])=O)C(F)(F)F
InChiKey: MKXKFYHWDHIYRV-UHFFFAOYSA-N
InChi: InChI=1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17)
Technical Data
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO, not in water
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
References:
- Simard J, et al. Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues. Mol Cell Endocrinol. 1986 Mar;44(3):261-70.
- Luthy IA, et al. Androgenic activity of synthetic progestins and spironolactone in androgen-sensitive mouse mammary carcinoma (Shionogi) cells in culture. J Steroid Biochem. 1988 Nov;31(5):845-52.
- Crawford ED, et al. A controlled trial of leuprolide with and without flutamide in prostatic carcinoma. N Engl J Med. 1989 Aug 17;321(7):419-24.
Products are for research use only. Not for human use.
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