Description
JHU 37160 is a high affinity and highly potent activator of hM3Dq and hM4Di DREADDs. It displays approximately 25-fold higher affinity for hM4Di compared to DREADD agonist 21. It selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites. JHU 37160 inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons, and increases hM3Dq-stimulated locomotion in rats expressing hM3Dq in TH-expressing neurons. It is a brain penetrant in mice, rats and non-human primates.
Product information
CAS Number: 2369979-68-8
Molecular Weight: 358.84
Formula: C19H20ClFN4
Synonym:
JHU37160
JHU-37160
Chemical Name: 8-Chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5H-dibenzo[b, e][1, 4]diazepine
Smiles: CCN1CCN(CC1)C1=NC2=CC(Cl)=CC=C2NC2=C(F)C=CC=C21
InChiKey: SWSCWOSASZXIRK-UHFFFAOYSA-N
InChi: InChI=1S/C19H20ClFN4/c1-2-24-8-10-25(11-9-24)19-14-4-3-5-15(21)18(14)22-16-7-6-13(20)12-17(16)23-19/h3-7,12,22H,2,8-11H2,1H3
Technical Data
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
References:
- Bonaventura et al (2019) High-potency ligands for DREADD imaging and activation in rodents and monkeys. Nat.Commun. 10 4627 PMID: 31604917
Products are for research use only. Not for human use.
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