Description
ISRIB is an integrated stress response (ISR) inhibitor that potently reverses the effects of eukaryotic initiation factor 2α (eIF2α) phosphorylation with IC50 of 5 nM.
Product information
CAS Number: 548470-11-7
Molecular Weight: 451.34
Formula: C22H24Cl2N2O4
Chemical Name: 2-(4-Chlorophenoxy)-N-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide
Smiles: O=C(COC1C=CC(Cl)=CC=1)NC1CCC(CC1)NC(=O)COC1C=CC(Cl)=CC=1
InChiKey: HJGMCDHQPXTGAV-UHFFFAOYSA-N
InChi: InChI=1S/C22H24Cl2N2O4/c23-15-1-9-19(10-2-15)29-13-21(27)25-17-5-7-18(8-6-17)26-22(28)14-30-20-11-3-16(24)4-12-20/h1-4,9-12,17-18H,5-8,13-14H2,(H,25,27)(H,26,28)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO: 10 mg/mL(22.15 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Carmela Sidrauski, et al. Elife. 2013 May 28;2:e00498.
Products are for research use only. Not for human use.
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