Description
Metarrestin (ML246) is an orally active and specific perinucleolar compartment (PNC) inhibitor that disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription. Metarrestin blocks metastatic development and extends survival in mouse cancer models.
Product information
CAS Number: 1443414-10-5
Molecular Weight: 474.60
Formula: C31H30N4O
Chemical Name: Trans-4-(7-benzyl-4-imino-5,6-diphenyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-3-yl) cyclohexanol
Smiles: N=C1C2=C(N=CN1[C@@H]1CC[C@@H](O)CC1)N(CC1C=CC=CC=1)C(=C2C1C=CC=CC=1)C1C=CC=CC=1
InChiKey: WSMXAUJFLWRPNT-DIVCQZSQSA-N
InChi: InChI=1S/C31H30N4O/c32-30-28-27(23-12-6-2-7-13-23)29(24-14-8-3-9-15-24)34(20-22-10-4-1-5-11-22)31(28)33-21-35(30)25-16-18-26(36)19-17-25/h1-15,21,25-26,32,36H,16-20H2/t25-,26-
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO: 21 mg/mL(44.24 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Kevin J Frankowski, et al. Sci Transl Med. 2018 May 16;10(441):eaap8307.
Products are for research use only. Not for human use.
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