Description
BAY-885 is a highly potent and selective ERK5 inhibitor.
Product information
CAS Number: 2307249-33-6
Molecular Weight: 515.53
Formula: C25H28F3N7O2
Chemical Name: [2-amino-4-(trifluoromethoxy)phenyl]-[4-[7-(4-methylpiperazin-1-yl)pyrido[3,2-d]pyrimidin-4-yl]piperidin-1-yl]methanone
Smiles: CN1CCN(CC1)C1=CN=C2C(=NC=NC2=C1)C1CCN(CC1)C(=O)C1=CC=C(C=C1N)OC(F)(F)F
InChiKey: QXURFIGBRGWPQD-UHFFFAOYSA-N
InChi: InChI=1S/C25H28F3N7O2/c1-33-8-10-34(11-9-33)17-12-21-23(30-14-17)22(32-15-31-21)16-4-6-35(7-5-16)24(36)19-3-2-18(13-20(19)29)37-25(26,27)28/h2-3,12-16H,4-11,29H2,1H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO 30 mg/mL (58.19 mM) Ethanol 8 mg/mL (15.52 mM)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
BAY-885 shows potent ERK5 kinase and transcriptional inhibition in the SN12C-MEF2 reporter cell line (IC50 = 115 nM/IC90 = 691 nM) and has no effects on a reporter control cell line with constitutive luciferase expression (SN12C-CMV-luc, IC50 > 30 μM), thereby ruling out potential effects as a general inhibitor of transcription or translation.
References:
- Duy Nguyen, et al. J Med Chem. 2019 Jan 24;62(2):928-940.
Products are for research use only. Not for human use.
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