Description
CB-103 is an orally active inhibitor of the Notch transcription activation complex. CB-103 produces Notch loss-of-function phenotypes in flies and mice and inhibits the growth of human breast cancer and leukemia xenografts.
Product information
CAS Number: 218457-67-1
Molecular Weight: 242.32
Formula: C15H18N2O
Synonym:
CB 103
CB103
Chemical Name: 5-Amino-2-(4-tert-butylphenoxy)pyridine
Smiles: CC(C)(C)C1C=CC(=CC=1)OC1=CC=C(N)C=N1
InChiKey: WHIWGRCYMQLLAO-UHFFFAOYSA-N
InChi: InChI=1S/C15H18N2O/c1-15(2,3)11-4-7-13(8-5-11)18-14-9-6-12(16)10-17-14/h4-10H,16H2,1-3H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO 48 mg/mL (198.09 mM) Ethanol 48 mg/mL (198.09 mM)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
CB-103 inhibits growth of Notch-addicted human T cell acute lymphoblastic leukemia cell lines through modulation of the Notch transcription complex.
In Vivo:
CB-103 function in vivo recapitulates genetic notch loss-of-function phenotypes without causing gut toxicity. CB-103 blocks tumor growth of GSI-resistant cancers.
References:
- Rajwinder Lehal, et al. Proc Natl Acad Sci U S A. 2020 Jul 14;1
Products are for research use only. Not for human use.
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