Description
UC-781 is a non-nucleoside reverse transcriptase inhibitor potenially for the treatment of HIV infection. In human cervical explant cultures, UC-781 was not only able to inhibit direct infection of mucosal tissue but was able to prevent dissemination of virus by migratory cells. UC-781 formulated into a carbopol gel (0.1%) retained significant activity against both direct tissue infection and transinfection mediated by migratory cells. Furthermore, UC-781 demonstrated prolonged inhibitory effects able to prevent both localized and disseminated infections up to 6 days post compound treatment.
Product information
CAS Number: 2315-97-1
Molecular Weight: 510.50
Formula: C28H22N4O6
Synonym:
NSC-151912
L-6868
Chemical Name: 10,10'-dimethyl-[9,9'-biacridine]-10,10'-diium nitrate
Smiles: C[N+]1C2=CC=CC=C2C(C2C3=CC=CC=C3[N+](C)=C3C=CC=CC3=2)=C2C=CC=CC=12.[O-]N(=O)=O.[O-]N(=O)=O
InChiKey: KNJDBYZZKAZQNG-UHFFFAOYSA-N
InChi: InChI=1S/C28H22N2.2NO3/c1-29-23-15-7-3-11-19(23)27(20-12-4-8-16-24(20)29)28-21-13-5-9-17-25(21)30(2)26-18-10-6-14-22(26)28;2*2-1(3)4/h3-18H,1-2H3;;/q+2;2*-1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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