Description
Arecoline Hydrobromide is a muscarinic and nicotinic acetylcholine receptor agonist. Results indicate that the effect of arecoline on rat hepaticdoes not involve transcriptional activation of the gene, but largely involves the stabilization of CYP2E1 protein against degradation or increased efficiency of CYP2E1 mRNA translation, and additionally involve the post- ranslational modification of CYP2E1 protein. Furthermore, the CYP2E1 response is fairly equal among the different species, the induction of rat hepatic CYP2E1 by arecoline suggests that there is a risk of metabolic interaction among the substrate drugs of CYP2E1 in betel-quid use human.
Product information
CAS Number: 300-08-3
Molecular Weight: 236.11
Formula: C8H14BrNO2
Synonym:
Arecoline bromide
Taeniolin
Chemical Name: methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate hydrobromide
Smiles: Br.CN1CC(=CCC1)C(=O)OC
InChiKey: AXOJRQLKMVSHHZ-UHFFFAOYSA-N
InChi: InChI=1S/C8H13NO2.BrH/c1-9-5-3-4-7(6-9)8(10)11-2;/h4H,3,5-6H2,1-2H3;1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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