Description
Pemetrexed Disodium Hydrate (LY-231514) is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. Pemetrexed Disodium Hydrate stimulates autophagy and apoptosis.
Product information
CAS Number: 357166-30-4
Molecular Weight: 1032.83
Formula: C40H48N10Na4O17
Chemical Name: tetrasodium bis((2S)-2-{[4-(2-{2-amino-4-oxo-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)phenyl]formamido}pentanedioate) pentahydrate
Smiles: O.O.O.O.O.[Na+].[Na+].[Na+].[Na+].NC1NC(=O)C2=C(NC=C2CCC2C=CC(=CC=2)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)N=1.NC1NC(=O)C2=C(NC=C2CCC2C=CC(=CC=2)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)N=1
InChiKey: ZCTCZKWJFTYNMZ-WKUCUCPSSA-J
InChi: InChI=1S/2C20H21N5O6.4Na.5H2O/c2*21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27;;;;;;;;;/h2*1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29);;;;;5*1H2/q;;4*+1;;;;;/p-4/t2*13-;;;;;;;;;/m00........./s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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