TPT-260 dihydrochloride


Catalog No. Size PriceQuantity
M9749-2 Solid 2 mg $90
M9749-10 Solid 10 mg $270

Description

TPT-260 2HCl, also known as R55, is a thiophene thiourea derivative with molecule weight 260.00 in free base form. There is no formal name yet, we temporally call this molecule as TPT-260. TPT260 acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~ 5 µM). In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP.****Please also see similar products: TPT-197; TPT-260; TPT-172.

Product information

CAS Number: 2076-91-7

Molecular Weight: 333.32

Formula: C8H14Cl2N4S3

Chemical Name: [({5-[(carbamimidoylsulfanyl)methyl]thiophen-2-yl}methyl)sulfanyl]methanimidamide dihydrochloride

Smiles: Cl.Cl.NC(=N)SCC1=CC=C(CSC(N)=N)S1

InChiKey: DSODRWWHAUGSGD-UHFFFAOYSA-N

InChi: InChI=1S/C8H12N4S3.2ClH/c9-7(10)13-3-5-1-2-6(15-5)4-14-8(11)12;;/h1-2H,3-4H2,(H3,9,10)(H3,11,12);2*1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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