GLPG0492


Catalog No. Size PriceQuantity
M9842-2 Solid 2 mg $130
M9842-10 Solid 10 mg $390

Description

GLPG-0492, also known as DT-200, is a non-steroidal selective androgen receptor modulator potentially for the treatment of Duchenne muscular dystrophy. GLPG0492 treatment partially prevents immobilization-induced muscle atrophy with a trend to promote muscle fiber hypertrophy in a dose-dependent manner. Gene expression studies performed on tibialis samples revealed that both GLPG0492 was slowing down muscle loss by negatively interfering with major signaling pathways controlling muscle mass homeostasis.

Product information

CAS Number: 1215085-92-9

Molecular Weight: 389.33

Formula: C19H14F3N3O3

Synonym:

DT200

DT 200

DT-200

Chemical Name: 4-[(4S)-4-(hydroxymethyl)-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Smiles: CN1C(=O)N(C2=CC(=C(C=C2)C#N)C(F)(F)F)C(=O)[C@@]1(CO)C1C=CC=CC=1

InChiKey: VAJGULUVTFDTAS-GOSISDBHSA-N

InChi: InChI=1S/C19H14F3N3O3/c1-24-17(28)25(14-8-7-12(10-23)15(9-14)19(20,21)22)16(27)18(24,11-26)13-5-3-2-4-6-13/h2-9,26H,11H2,1H3/t18-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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