Description
GLPG-0492, also known as DT-200, is a non-steroidal selective androgen receptor modulator potentially for the treatment of Duchenne muscular dystrophy. GLPG0492 treatment partially prevents immobilization-induced muscle atrophy with a trend to promote muscle fiber hypertrophy in a dose-dependent manner. Gene expression studies performed on tibialis samples revealed that both GLPG0492 was slowing down muscle loss by negatively interfering with major signaling pathways controlling muscle mass homeostasis.
Product information
CAS Number: 1215085-92-9
Molecular Weight: 389.33
Formula: C19H14F3N3O3
Synonym:
DT200
DT 200
DT-200
Chemical Name: 4-[(4S)-4-(hydroxymethyl)-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile
Smiles: CN1C(=O)N(C2=CC(=C(C=C2)C#N)C(F)(F)F)C(=O)[C@@]1(CO)C1C=CC=CC=1
InChiKey: VAJGULUVTFDTAS-GOSISDBHSA-N
InChi: InChI=1S/C19H14F3N3O3/c1-24-17(28)25(14-8-7-12(10-23)15(9-14)19(20,21)22)16(27)18(24,11-26)13-5-3-2-4-6-13/h2-9,26H,11H2,1H3/t18-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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