Description
IRAK4-IN-6 is an orally efficacious and selective IRAK4 inhibitor with an IC50 of 4 nM, and targetes MyD88 L265P mutant diffuse large B cell lymphoma.
Product information
CAS Number: 2454244-02-9
Molecular Weight: 504.59
Formula: C25H32N10O2
Chemical Name: methyl 4-[(1r,4r)-4-{[6-(cyanomethyl)-2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrido[3,2-d]pyrimidin-4-yl]amino}cyclohexyl]piperazine-1-carboxylate
Smiles: CN1C=C(C=N1)NC1=NC2=CC=C(CC#N)N=C2C(N[C@@H]2CC[C@H](CC2)N2CCN(CC2)C(=O)OC)=N1
InChiKey: RPGMSHCJIWHISY-IRJFHVNHSA-N
InChi: InChI=1S/C25H32N10O2/c1-33-16-19(15-27-33)30-24-31-21-8-5-18(9-10-26)28-22(21)23(32-24)29-17-3-6-20(7-4-17)34-11-13-35(14-12-34)25(36)37-2/h5,8,15-17,20H,3-4,6-7,9,11-14H2,1-2H3,(H2,29,30,31,32)/t17-,20-
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 125 mg/mL (247.73 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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