PF-06426779 - CAS# 1817628-40-2


Catalog No. Size PriceQuantity
M16645-C Contact sales@xcessbio.com for quotation $100

Description

PF-06426779 is a potent and selective inhibitor of interleukin‑1 receptor associated kinase 4 (IRAK4), with an IC50 of 0.3 nM.

Product information

CAS Number: 1817628-40-2

Molecular Weight: 347.34

Formula: C17H18FN3O4

Chemical Name: 1-(((2S, 3S, 4S)-4-fluoro-3-methyl-5-oxopyrrolidin-2-yl)methoxy)-7-methoxyisoquinoline-6-carboxamide

Smiles: C[C@@H]1[C@H](F)C(=O)N[C@@H]1COC1=NC=CC2C=C(C(N)=O)C(=CC1=2)OC

InChiKey: GISRWBROCYNDME-PELMWDNLSA-N

InChi: InChI=1S/C17H18FN3O4/c1-8-12(21-16(23)14(8)18)7-25-17-10-6-13(24-2)11(15(19)22)5-9(10)3-4-20-17/h3-6,8,12,14H,7H2,1-2H3,(H2,19,22)(H,21,23)/t8-,12+,14-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (719.76 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PF-06426779 inhibits IRAK4, with an IC50 of 12.7 nM in the peripheral blood mononuclear cells (PBMCs) assay.

Products are for research use only. Not for human use.

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