MDM2, one of the strongest inhibitors of apoptosis discovered so far, is an oncogene closely related to malignant tumors. It can regulate multiple functions of p53, including directly blocking the n-terminal transcriptional activation domain of p53, promoting the transfer of p53 from the nucleus to the cytoplasm, and ubiquitination of p53 as an E3 ligase, thereby degrading p53.
Amifostine
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Amifostine thiol
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Amifostine thiol dihydrochloride
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BH3I-1
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CP-31398 dihydrochloride
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DPBQ
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HLI 373 dihydrochloride
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Idasanutlin
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Inauhzin
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Kevetrin hydrochloride
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MI-773
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NSC 146109 hydrochloride
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NSC 66811
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NSC-207895
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Nutlin 3a
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Nutlin-3, (4R5S, and 4S5R)
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Nutlin-3b
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NVP-CGM097
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p53 (17-26)
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Pifithrin-α hydrobromide
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Pifithrin-β
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