ML-9 Free Base - CAS# 110448-31-2


Catalog No. Size PriceQuantity
M17374-C Contact sales@xcessbio.com for quotation $100

Description

ML-9 (Free Base) is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity. ML-9 (Free Base) inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively. ML-9 (Free Base) induces autophagy by stimulating autophagosome formation and inhibiting their degradation.

Product information

CAS Number: 110448-31-2

Molecular Weight: 324.83

Formula: C15H17ClN2O2S

Chemical Name: 1-[(5-chloronaphthalen-1-yl)sulfonyl]-1,4-diazepane

Smiles: O=S(=O)(C1C=CC=C2C(Cl)=CC=CC=12)N1CCCNCC1

InChiKey: OZSMSRIUUDGTEP-UHFFFAOYSA-N

InChi: InChI=1S/C15H17ClN2O2S/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18/h1-2,4-7,17H,3,8-11H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

ML9 (Free Base) (0-100 μM; 0-24 hours) has no reduction in cardiomyocyte viability, 50-100 μM significantly induces cell death. ML9 (Free Base) (50 μM; 1-4 hours) significantly increases cleaved caspase-3 levels, decreased STIM1 protein levels by about 42%.

Products are for research use only. Not for human use.

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