SBC-115337 - CAS# 423148-46-3


Catalog No. Size PriceQuantity
M16328-C Contact sales@xcessbio.com for quotation $100

Description

SBC-115337, as a potent benzofuran compound, is a PCSK9 inhibitor with an IC50 value of 0.5 μM.

Product information

CAS Number: 423148-46-3

Molecular Weight: 473.48

Formula: C29H19N3O4

Chemical Name: N-(4-{[4-(1,3-benzoxazol-2-yl)phenyl]carbamoyl}phenyl)-1-benzofuran-2-carboxamide

Smiles: O=C(NC1C=CC(=CC=1)C(=O)NC1C=CC(=CC=1)C1=NC2=CC=CC=C2O1)C1=CC2=CC=CC=C2O1

InChiKey: ALQIZRCPSILFNQ-UHFFFAOYSA-N

InChi: InChI=1S/C29H19N3O4/c33-27(30-21-15-11-19(12-16-21)29-32-23-6-2-4-8-25(23)36-29)18-9-13-22(14-10-18)31-28(34)26-17-20-5-1-3-7-24(20)35-26/h1-17H,(H,30,33)(H,31,34)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

The potent compound (SBC-115,337) shows an IC50 of 0.6 μM measured in an in vitro ELISA assay to monitor the effect of PCSK9 binding to the recombinant LDLR. SBC-115,337 at 1.2 μM induces more than tenfold upregulation of LDLR in HepG2 cells with respect to the control, increases uptake of fluorescently labeled DiI-LDL and loweres LDL-c levels in mice fed a high-fat diet.

Products are for research use only. Not for human use.

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