Description
SBC-115337, as a potent benzofuran compound, is a PCSK9 inhibitor with an IC50 value of 0.5 μM.
Product information
CAS Number: 423148-46-3
Molecular Weight: 473.48
Formula: C29H19N3O4
Chemical Name: N-(4-{[4-(1,3-benzoxazol-2-yl)phenyl]carbamoyl}phenyl)-1-benzofuran-2-carboxamide
Smiles: O=C(NC1C=CC(=CC=1)C(=O)NC1C=CC(=CC=1)C1=NC2=CC=CC=C2O1)C1=CC2=CC=CC=C2O1
InChiKey: ALQIZRCPSILFNQ-UHFFFAOYSA-N
InChi: InChI=1S/C29H19N3O4/c33-27(30-21-15-11-19(12-16-21)29-32-23-6-2-4-8-25(23)36-29)18-9-13-22(14-10-18)31-28(34)26-17-20-5-1-3-7-24(20)35-26/h1-17H,(H,30,33)(H,31,34)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
The potent compound (SBC-115,337) shows an IC50 of 0.6 μM measured in an in vitro ELISA assay to monitor the effect of PCSK9 binding to the recombinant LDLR. SBC-115,337 at 1.2 μM induces more than tenfold upregulation of LDLR in HepG2 cells with respect to the control, increases uptake of fluorescently labeled DiI-LDL and loweres LDL-c levels in mice fed a high-fat diet.
Products are for research use only. Not for human use.
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