Patamostat mesylate - CAS# 114568-32-0


Catalog No. Size PriceQuantity
M17428-C Contact sales@xcessbio.com for quotation $100

Description

Patamostat (E-3123) mesylate is a potent protease inhibitor. Patamostat mesylate potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat mesylate may possess suppressing effects on pathogenesis and development of acute pancreatitis.

Product information

CAS Number: 114568-32-0

Molecular Weight: 508.57

Formula: C21H24N4O7S2

Chemical Name: 4-{[2-(2,5-dioxopyrrolidin-1-yl)ethyl]sulfanyl}phenyl 4-[(diaminomethylidene)amino]benzoate; methanesulfonic acid

Smiles: CS(O)(=O)=O.NC(N)=NC1C=CC(=CC=1)C(=O)OC1C=CC(=CC=1)SCCN1C(=O)CCC1=O

InChiKey: HTSFLDCSCNSKJW-UHFFFAOYSA-N

InChi: InChI=1S/C20H20N4O4S.CH4O3S/c21-20(22)23-14-3-1-13(2-4-14)19(27)28-15-5-7-16(8-6-15)29-12-11-24-17(25)9-10-18(24)26;1-5(2,3)4/h1-8H,9-12H2,(H4,21,22,23);1H3,(H,2,3,4)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Patamostat mesylate (intravenous infusion) at 0.03-0.3 mg/kg in rats or at 0.3-3.0 mg/kg in rabbits reduces mortality after the induction of pancreatitis in a dose-dependent manner. Patamostat mesylate (1.0-3.0 mg/kg; intravenous infusion) reduces the increases of serum trypsin and lipase activities in dogs with pancreatitis. Patamostat mesylate (2 mg/kg per h; continuous infusion) improves almost all parameters, including mortality rate, serum and ascitic fluid amylase levels, plasma endotoxin and serum FDP levels, and distribution of lysosomal enzyme in male Wistar rats.

Products are for research use only. Not for human use.

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